Question
Computational prediction of MiRNA target genes
Answer :
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Computational prediction of miRNA target genes is a core component of transcriptomics and functional genomics, enabling researchers to map post-transcriptional regulatory networks within OMICS frameworks. Since miRNAs bind primarily to complementary sequences in the 3′ UTR of mRNAs to repress translation or induce degradation, computational tools analyze sequence complementarity, thermodynamic stability, and evolutionary conservation to identify potential targets. Algorithms such as TargetScan, miRanda, PicTar, and RNAhybrid employ seed-region matching, where nucleotides 2–8 of the miRNA are considered the most critical for binding specificity. Conservation across species
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