Question
Write the steps involved in the Boots synthesis of ibuprofen.
Answer :
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The Boots synthesis of ibuprofen is an important industrial method used to produce ibuprofen efficiently and with fewer environmental hazards, aligning with the principles of green chemistry. The process begins with isobutylbenzene as the starting material. In the first step, isobutylbenzene undergoes Friedel-Crafts acylation with acetyl chloride in the presence of an AlCl₃ catalyst to form 4-isobutylacetophenone. This reaction introduces the necessary carbonyl group while maintaining high selectivity. Next, the ketone group in 4-isobutylacetophenone is oxidized to a carboxylic acid derivative. Traditionally, this
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