Question
How did Emil Fischer synthesise purine? Give the sequence of reactions.
Answer :
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Emil Fischer synthesised purine through a classical multistep approach starting from simple readily available precursors, demonstrating the systematic construction of the fused imidazole–pyrimidine framework. The synthesis began with the preparation of 4,5-diaminopyrimidine, which served as the key heterocyclic intermediate. Fischer first converted barbituric acid derivatives into suitable pyrimidine systems using controlled
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