IGNOU BBCCT 105 2026 - Explain the principle of Edman degradation for protein seque

Question

Explain the principle of Edman degradation for protein sequencing.

09 Feb 2026

Answer :

Word Count : 200

Edman degradation is a technique used for sequencing proteins by systematically removing one amino acid at a time from the N-terminal end of a polypeptide chain. The process involves the reaction of the amino-terminal residue with phenylisothiocyanate (PITC) under mildly alkaline conditions. This forms a phenylthiohydantoin (PTH) derivative of the

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