Question
Describe patho- physiology of Nephrotic Syndrome.
Answer :
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Nephrotic syndrome is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia resulting from increased permeability of the glomerular membrane. In children, the most common cause is minimal change disease, in which there is damage to the podocytes of the glomeruli. The basic pathophysiology begins with injury to the glomerular filtration barrier, which consists of the capillary endothelium, basement membrane, and epithelial cells. This damage increases the permeability of the membrane, allowing large amounts of plasma proteins, especially albumin,
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