Question
Compare the fidelity of transcription and DNA replication and discuss the biological significance of transcriptional errors.
Answer :
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DNA replication and transcription are both processes that involve copying genetic information, but they differ significantly in fidelity. DNA replication is highly accurate, with error rates as low as 1 in 10⁹–10¹⁰ nucleotides, due to the proofreading activity of DNA polymerases and the post-replication mismatch repair mechanisms. This high fidelity is essential because errors in DNA replication are permanent and
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